Wilson’s Pharmacy, at the corner of Penn Avenue and Main Street, is one of the mainstays of the business district.
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Easy Access to Pittsburgh’s Eastern Neighborhoods
Sitting at the upper section of Pittsburgh’s Lawrenceville neighborhood, the Penn Main Business District provides easy access to the adjacent neighborhoods of Bloomfield, Friendship, Garfield, and the Strip District. Our district takes its name from the intersection at Penn Avenue and Main Street, which connects Bloomfield to Lawrenceville’s Butler Street Business District. Our district is also within 10 minutes’ drive to the heart of the Oakland neighborhood, home to the city’s major medical and educational institutions.
>>View and download a district map
>>View a list of Port Authority buses serving the Penn Main District |

Brillobox, a bar, eatery and entertainment venue, is a popular destination to relax and hear live music.
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Serving Residents and Visitors
The Penn Main Business District is home to businesses that serve the neighboring residential communities of Lawrenceville and Bloomfield, as well as visitors from around the city. Upon the arrival of Children’s Hospital of Pittsburgh, our district will serve visitors from around the region seeking pediatric medical care.
>>Browse our Business Directory
>>Learn about the Penn Main Business Association
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